Back to Search
Start Over
Cough sensitivity in localized scleroderma with no clinical symptoms from lower airways.
- Source :
-
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society [J Physiol Pharmacol] 2003 Sep; Vol. 54 Suppl 1, pp. 25-8. - Publication Year :
- 2003
-
Abstract
- Cough sensitivity is increased in patients with atopic dermatitis, although they have no clinical symptoms from the lower airways. In the present study we examined the cough sensitivity to capsaicin in patients, who had no clinical respiratory symptoms, with sclerodermia localized to the skin. Cough sensitivity was defined as the lowest capsaicin concentration, which evokes 2 or more coughs. Twelve patients and 12 healthy matched volunteers, as a comparison group, inhaled deep breaths (2 L) of a capsaicin aerosol in doubled concentrations (from 0.02 to 200 micromol/L). Cough sensitivity, expressed as a geometric mean (95% CI) of capsaicin concentration, was 0.15 micromol/L (0.04 to 0.56) in the patients with localized sclerodermia and 4.96 micromol/L (2.50 to 9.85) in controls, which made a significant difference towards higher cough sensitivity in sclerodermia, respiratory symptom-free patients. Thus, disease processes localized outside the respiratory tract may have surreptitious pulmonary manifestation that is brought to light by the capsaicin cough test.
- Subjects :
- Adult
Bronchial Hyperreactivity chemically induced
Bronchial Hyperreactivity complications
Bronchial Hyperreactivity physiopathology
Capsaicin adverse effects
Cough chemically induced
Cough complications
Female
Humans
Lung drug effects
Male
Middle Aged
Scleroderma, Localized complications
Cough physiopathology
Lung physiology
Scleroderma, Localized physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1899-1505
- Volume :
- 54 Suppl 1
- Database :
- MEDLINE
- Journal :
- Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
- Publication Type :
- Academic Journal
- Accession number :
- 15886407