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Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study.
- Source :
-
Archives of internal medicine [Arch Intern Med] 2005 May 23; Vol. 165 (10), pp. 1179-84. - Publication Year :
- 2005
-
Abstract
- Background: The risk of diabetes mellitus (DM) in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) has not been well defined.<br />Methods: We conducted an analysis in the Multicenter AIDS Cohort Study to determine the prevalence and incidence of DM in this cohort of HIV-infected and HIV-seronegative men. Prevalence analysis included 1278 men (710 HIV seronegative and 568 HIV infected, 411 receiving HAART) with fasting glucose concentration determinations at baseline. Incidence analysis included 680 of these 1278 men who at the baseline visit had a fasting glucose concentration of 98 mg/dL (5.4 mmol/L) or less, no self-reported history of DM, and no self-reported use of antidiabetic medication. Diabetes mellitus was defined as a fasting glucose concentration of 126 mg/dL (7 mmol/L) or higher, self-reported diagnosis of DM, or self-reported use of antidiabetic medication.<br />Results: Fifty-seven (14%) of the 411 HIV-infected men using HAART at the baseline visit had prevalent DM compared with 33 (5%) of the 711 HIV-seronegative men (prevalence ratio = 4.6; 95% confidence interval, 3.0-7.1, adjusted for age and body mass index [calculated as weight in kilograms divided by the square of height in meters]). The rate of incident DM was 4.7 cases per 100 person-years among HIV-infected men using HAART compared with 1.4 cases per 100 person-years among HIV-seronegative men (rate ratio = 4.11; 95% confidence interval, 1.85-9.16, adjusted for age and body mass index), during the 4-year observation period, based on a median follow-up of 2.3 years.<br />Conclusion: The incidence of DM in HIV-infected men with HAART exposure was greater than 4 times that of HIV-seronegative men, representing a risk that is higher than previous estimates.
- Subjects :
- Acquired Immunodeficiency Syndrome complications
Acquired Immunodeficiency Syndrome virology
Adult
Blood Glucose metabolism
CD4 Lymphocyte Count
Confidence Intervals
Diabetes Mellitus blood
Diabetes Mellitus chemically induced
Follow-Up Studies
Glucose Tolerance Test
HIV immunology
HIV Antibodies immunology
Humans
Incidence
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
United States epidemiology
Acquired Immunodeficiency Syndrome drug therapy
Antiretroviral Therapy, Highly Active adverse effects
Diabetes Mellitus epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9926
- Volume :
- 165
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15911733
- Full Text :
- https://doi.org/10.1001/archinte.165.10.1179