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[Effects of Chinese herb compound on myocardial SDH, ATP-ase and energy reserves in tail-suspended rats].
- Source :
-
Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering [Space Med Med Eng (Beijing)] 2004 Oct; Vol. 17 (5), pp. 326-9. - Publication Year :
- 2004
-
Abstract
- Objective: To investigate effects of Chinese herb compound on myocardial SDH, ATP-ase and energy reserves in tail-suspended rats.<br />Method: Male SD rats were randomly divided into three groups (n=10 each): (A) normal control group; (B) tail-suspended group; (C) tail-suspended + Chinese Medical herb compound group. Rats in group B and C were tail-suspended (-30 degrees) for 5 d to simulate weightlessness. All rats B were decapitated after the experiment. Myocardial SDH (method of Anderson N-BT), ATP-ase (method of Wachstein and Meisel) and energy reserves (method of HPLC) were examined.<br />Result: Compared with rats in groups A and C, SDH activity increased, SDH staining deepened, value of OD SDH enhanced, ATP-ase activity and OD value increased and enhanced significantly (P<0.01) but value of myocardial energy reserves decreased in group B rats.<br />Conclusion: Tail-suspension strengthens compensatory oxidation metabolism of cardiac muscle and activates SDH and ATP-ase, at the same time decrease, myocardial energy reserves. Normal are maintained the low level of metabolism by the medical herb compound used which shows a protecting effects through mitigation, tranguilization and replenishment of Qi.
- Subjects :
- Adenosine Triphosphatases metabolism
Animals
Energy Metabolism drug effects
Heart drug effects
Hindlimb Suspension
Male
Myocardium metabolism
Rats
Rats, Sprague-Dawley
Succinate Dehydrogenase metabolism
Adenosine Triphosphatases drug effects
Drugs, Chinese Herbal pharmacology
Myocardium enzymology
Succinate Dehydrogenase drug effects
Weightlessness Simulation
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1002-0837
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering
- Publication Type :
- Academic Journal
- Accession number :
- 15926228