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Toward improved immunocompetence of adoptively transferred CD8+ T cells.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2005 Jun; Vol. 115 (6), pp. 1467-9. - Publication Year :
- 2005
-
Abstract
- Adoptive transfer of autologous or allogenic T cells to patients is being used with increased frequency as a therapy for infectious diseases and cancer. However, many questions remain with regard to defining optimized procedures for preparation and selection of T cell populations for transfer. In a new study in this issue of the JCI, Gattinoni and colleagues used a TCR transgenic mouse model to examine in vitro-generated tumor antigen-specific CD8+ T cells at various stages of differentiation for their efficacy in adoptive immunotherapy against transplantable melanoma. The results confirm that CD8+ T cells progressively lose immunocompetence with prolonged in vitro cultivation and suggest that effector CD8+ T cells alone may be considerably less potent at protecting hosts with advanced tumors than are less differentiated T cells.
- Subjects :
- Animals
CD8-Positive T-Lymphocytes transplantation
Cell Differentiation immunology
Humans
Immunity, Cellular
Melanoma therapy
Mice
Transplantation, Autologous
Transplantation, Homologous
CD8-Positive T-Lymphocytes immunology
Immunotherapy, Adoptive
Melanoma immunology
Neoplasms, Experimental immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9738
- Volume :
- 115
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 15931384
- Full Text :
- https://doi.org/10.1172/JCI25427