Back to Search
Start Over
Stereoselective synthesis of new conformationally restricted analogues of a potent CGRP receptor antagonist.
- Source :
-
Organic letters [Org Lett] 2005 Jun 09; Vol. 7 (12), pp. 2465-8. - Publication Year :
- 2005
-
Abstract
- [structures: see text] A stereocontrolled racemic synthesis of conformationally restricted analogues 2a and 2b of a potent CGRP receptor antagonist 1 by novel functionalization of 2-substituted octahydropyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted alpha-nitration of intermediate lactams established the required trans-configuration in the desired products.
- Subjects :
- Benzimidazoles chemistry
Crystallography, X-Ray
Lactams chemistry
Molecular Conformation
Molecular Structure
Piperazines chemistry
Piperidines chemistry
Stereoisomerism
Benzimidazoles chemical synthesis
Calcitonin Gene-Related Peptide Receptor Antagonists
Piperazines chemical synthesis
Piperidines chemical synthesis
Pyrazines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 7
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 15932224
- Full Text :
- https://doi.org/10.1021/ol0510062