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Zinc protects renal function during cadmium intoxication in the rat.
- Source :
-
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2006 Jan; Vol. 290 (1), pp. F127-37. Date of Electronic Publication: 2005 Jun 07. - Publication Year :
- 2006
-
Abstract
- This study investigates the effect in the rat of chronic CdCl2 intoxication (500 microg Cd2+/kg, daily i.p. injection for 5 days) on renal function and the changes in tight junction proteins claudin-2, claudin-3, and claudin-5 present in rat kidney. We also studied the effect of coadministration of ZnCl2 (500 microg Zn2+/kg) during chronic CdCl2 intoxication. Our results indicate that 1) most of the filtered Cd2+ is reabsorbed within the kidney; 2) chronic Cd2+ intoxication can induce a change in renal handling of ions without altering glomerular filtration rate; 3) a delayed nephropathy, showing Fanconi-like features, appears more than 5 days after the end of CdCl2 exposure; 4) epithelial integrity is altered by chronic Cd2+ intoxication affecting the expression and localization of claudin tight junction proteins; and 5) cotreatment with Zn2+ protects against the renal toxic effects of Cd2+, preventing altered claudin expression and inhibiting apoptosis. In conclusion, these results show that Cd2+ toxicity and cellular toxic mechanisms are complex, probably affecting both membrane transporters and tight junction proteins. Finally, Zn2+ supplementation may provide a basis for future treatments.
- Subjects :
- Animals
Apoptosis
Body Weight drug effects
Cadmium Poisoning metabolism
Claudin-3
Claudins
Female
Glomerular Filtration Rate drug effects
Ions blood
Membrane Proteins metabolism
Rats
Rats, Wistar
Tight Junctions metabolism
Urination drug effects
Cadmium Poisoning physiopathology
Kidney physiopathology
Zinc pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1931-857X
- Volume :
- 290
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Renal physiology
- Publication Type :
- Academic Journal
- Accession number :
- 15942048
- Full Text :
- https://doi.org/10.1152/ajprenal.00366.2004