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Safety and effectiveness of olanzapine in monotherapy: a multivariate analysis of a naturalistic study.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2005 Jul; Vol. 29 (6), pp. 944-51. - Publication Year :
- 2005
-
Abstract
- Background: This study investigated safety and effectiveness of olanzapine in monotherapy compared with conventional antipsychotics in treatment of acute inpatients with schizophrenia.<br />Method: This was a prospective, comparative, nonrandomized, open-label, multisite, observational study of Spanish inpatients with an acute episode of schizophrenia. Data included safety assessments with an extrapyramidal symptoms (EPS) questionnaire and the report of spontaneous adverse events, plus clinical assessments with the Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impressions-Severity of Illness (CGI-S). A multivariate methodology was used to more adequately determine which factors can influence safety and effectiveness of olanzapine in monotherapy.<br />Results: 339 patients treated with olanzapine in monotherapy (OGm) and 385 patients treated with conventional antipsychotics (CG) were included in the analysis. Treatment-emergent EPS were significantly higher in the CG (p<0.0001). Response rate was significantly higher in the OGm (p=0.005). Logistic regression analyses revealed that the only variable significantly correlated with treatment-emergent EPS and clinical response was treatment strategy, with patients in OGm having 1.5 times the probability of obtaining a clinical response and patients in CG having 5 times the risk of developing EPS.<br />Conclusion: In this naturalistic study olanzapine in monotherapy was better-tolerated and at least as effective as conventional antipsychotics.
- Subjects :
- Adult
Antipsychotic Agents adverse effects
Basal Ganglia Diseases drug therapy
Basal Ganglia Diseases etiology
Benzodiazepines adverse effects
Benzodiazepines therapeutic use
Demography
Dose-Response Relationship, Drug
Female
Haloperidol therapeutic use
Humans
Logistic Models
Male
Middle Aged
Olanzapine
Prospective Studies
Risk
Schizophrenia complications
Severity of Illness Index
Treatment Outcome
Antipsychotic Agents therapeutic use
Multivariate Analysis
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0278-5846
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15950351
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2005.04.037