Body weight gain induced by a newer antipsychotic agent reversed as negative symptoms improved.

Objective: We describe a patient in whom improvement in negative symptoms contributed to early weight loss and subsequent long-term improvement in weight management.
Method: Case report.
Results: A 26-year-old woman with schizophrenia gained 7 kg over the course of 1 year after starting treatment with olanzapine. However, as negative symptoms gradually improved with treatment, she became motivated to diet and exercise regularly. She quickly lost 9 kg and subsequently maintained optimal weight (55 kg; body mass index, 24.1 kg/m(2) ).
Conclusion: Important strategies for minimizing weight gain in patients taking antipsychotic agents include improving negative symptoms of avolition and apathy, regular monitoring of body weight and potential medical consequences of overweight and obesity, and educating the patient about the importance of diet and regular exercise.