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Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Jul 15; Vol. 15 (14), pp. 3328-32. - Publication Year :
- 2005
-
Abstract
- Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.
- Subjects :
- Animals
Benzamides chemical synthesis
Benzamides pharmacology
Benzamides therapeutic use
Benzothiazoles chemical synthesis
Benzothiazoles pharmacology
Benzothiazoles therapeutic use
Cell Line, Tumor
Cell Proliferation drug effects
Drug Design
Female
Humans
Mice
Molecular Structure
Structure-Activity Relationship
Time Factors
Xenograft Model Antitumor Assays
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Lung Neoplasms drug therapy
Thiazoles chemical synthesis
Thiazoles pharmacology
Thiazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15955697
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.05.077