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Adenosine infusion increases plasma levels of VEGF in humans.
- Source :
-
BMC physiology [BMC Physiol] 2005 Jun 20; Vol. 5, pp. 10. Date of Electronic Publication: 2005 Jun 20. - Publication Year :
- 2005
-
Abstract
- Background: Many in vitro studies have shown that adenosine (Ado) can induce vascular endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to determine whether Ado can increase circulating levels of VEGF protein in the intact human.<br />Methods: Five outpatients 49.3 +/- 6.7 years of age and weighing 88.2 +/- 8.5 kg were selected. They were given a 6 min intravenous infusion of Ado (0.14 mg kg-1 min-1) in conjunction with sestamibi myocardial perfusion scans. Mean blood pressure (MBP, calculated from systolic and diastolic values) and heart rate (HR) were determined before Ado infusion and every 2 min for the next 10 min. Plasma VEGF concentrations (ELISA) were determined immediately before Ado infusion and 1 h, 2 h, and 8 h after the infusion.<br />Results: Plasma VEGF concentration averaged 20.3 +/- 2.0 pg ml-1 prior to Ado infusion, and increased to 62.7 +/- 18.1 pg ml-1 at 1 h post- infusion (p < 0.01). VEGF plasma concentration returned to basal levels 2 h after infusion (23.3 +/- 3.4 pg ml-1). MBP averaged 116 +/- 7 mmHg and heart rate averaged 70 +/- 7 prior to Ado infusion. MBP decreased by a maximum of approximately 22% and HR increased by a maximum of approximately 17% during the infusion.<br />Conclusion: We conclude from these preliminary findings that intravenous infusion of adenosine can increase plasma levels of VEGF in humans.
- Subjects :
- Adenosine pharmacology
Blood Pressure drug effects
Female
Heart Rate drug effects
Humans
Infusions, Intravenous
Male
Middle Aged
Osmolar Concentration
Vasodilator Agents pharmacology
Adenosine administration & dosage
Vascular Endothelial Growth Factor A blood
Vasodilator Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1472-6793
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- BMC physiology
- Publication Type :
- Academic Journal
- Accession number :
- 15967042
- Full Text :
- https://doi.org/10.1186/1472-6793-5-10