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Detection of autoimmune regulator gene mutations in children with type 2 autoimmune hepatitis and extrahepatic immune-mediated diseases.
- Source :
-
The Journal of pediatrics [J Pediatr] 2005 Jun; Vol. 146 (6), pp. 839-42. - Publication Year :
- 2005
-
Abstract
- Autoimmune regulator gene mutations were identified in 3 children with type 2 autoimmune hepatitis and extrahepatic immune diseases, including 1 child with immune hepatitis recurrence after liver transplantation. These findings suggest that autoimmune regulator gene variants might predispose children to systemic autoimmune disease, a recurrence of immune disease, or both.
- Subjects :
- Adolescent
Adult
Blotting, Western
Child, Preschool
Exons
Female
Humans
Infant
Male
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
AIRE Protein
Autoantibodies blood
Cytochrome P-450 Enzyme System immunology
Hepatitis, Autoimmune genetics
Mutation
Polyendocrinopathies, Autoimmune immunology
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 146
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 15973329
- Full Text :
- https://doi.org/10.1016/j.jpeds.2005.01.050