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Grayanane diterpenoids from the flowers of Rhododendron molle with cytotoxic activity against a Spodoptera frugiperda cell line.
- Source :
-
Journal of natural products [J Nat Prod] 2005 Jun; Vol. 68 (6), pp. 924-6. - Publication Year :
- 2005
-
Abstract
- Two new grayanane diterpenoids, rhodomolins A (1) and B (2), together with two known diterpenoids, rhodomolleins I and rhodojaponin III, were isolated from the flowers of Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of interpretation of spectroscopic data. All compounds were evaluated for cytotoxic activity against the Spodoptera frugiperda cell line Sf-9 and gave IC(50) values in the range 12-80 microg/mL.
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
China
Diterpenes chemistry
Diterpenes pharmacology
Drug Screening Assays, Antitumor
Flowers chemistry
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Spodoptera cytology
Spodoptera drug effects
Antineoplastic Agents, Phytogenic isolation & purification
Diterpenes isolation & purification
Plants, Medicinal chemistry
Rhododendron chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 68
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 15974620
- Full Text :
- https://doi.org/10.1021/np049645t