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Prognostic role of minimal residual disease in multiple myeloma patients after non-myeloablative allogeneic transplantation.
- Source :
-
Leukemia research [Leuk Res] 2005 Aug; Vol. 29 (8), pp. 961-6. - Publication Year :
- 2005
-
Abstract
- This study evaluates the prognostic value of molecular monitoring of minimal residual disease (MRD) in 20 patients with multiple myeloma (MM) following autologous (peripheral blood stem cell transplantation, PBSCT) and non-myeloablative allogeneic (NMT) transplant. All patients completed their program, with a treatment-related mortality (TRM) of 20% and a 2-year progression-free survival (PFS) of 51%. After PBSCT, only 3 patients (15%) achieved PCR-negativity, versus 12 (60%) after NMT. The eradication of MRD had a favorable impact on 2-year OS. In fact, 76% of patients with no detectable MRD was still alive versus 34% of persistently IgH-positive cases (p=0.03). PCR status did not correlate with chimerism percentage: Seventy-five percent of patients achieved full donor chimerism, which was more frequently observed in cases presenting cGHVD (p=0.01). These data sustain the relevant role of molecular monitoring in MM patients undergoing NMT. MRD monitoring would assist physicians in making additional therapeutic decisions to better control this hematological malignancy.
- Subjects :
- Adult
Aged
Electrophoresis, Capillary
Female
Hematopoietic Stem Cell Transplantation adverse effects
Humans
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation adverse effects
Polymerase Chain Reaction
Prognosis
Prospective Studies
Sensitivity and Specificity
Survival Analysis
Transplantation, Autologous
Transplantation, Homologous
Hematopoietic Stem Cell Transplantation methods
Multiple Myeloma diagnosis
Multiple Myeloma therapy
Neoplasm, Residual diagnosis
Neoplasm, Residual therapy
Peripheral Blood Stem Cell Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 0145-2126
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 15978948
- Full Text :
- https://doi.org/10.1016/j.leukres.2005.01.017