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Evaluation of the cytotoxicity, cytostaticity and genotoxicity of argentatins A and B from Parthenium argentatum (Gray).
- Source :
-
Life sciences [Life Sci] 2005 Oct 14; Vol. 77 (22), pp. 2855-65. - Publication Year :
- 2005
-
Abstract
- Argentatins A and B are abundant triterpenes present in Parthenium argentatum. Both compounds have shown cytotoxic properties on K562, MCF-7, PC-3, HCT-15 and U251 human cancer cell lines. Furthermore the cytotoxic, cytostatic and genotoxic effects of the argentatins on proliferating lymphocytes were evaluated using cytokinesis-block micronucleus test. Argentatin A had no cytostatic properties, but it was cytotoxic for proliferating lymphocytes at a concentration of 25 microM (P < 0.005). On the other hand, argentatin B showed significant cytostatic effects (P < 0.001) at concentrations of 5 to 25 microM and it did not show cytotoxic effects at the same concentrations. Neither argentatin showed genotoxic effects in terms of micronucleus frequency in human lymphocytes. According to these results the argentatins are not able to cause injury on DNA by clastogenic or aneugenic mechanisms.
- Subjects :
- Adult
Analysis of Variance
Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Cell Line, Tumor
Cell Nucleus Division drug effects
Cell Proliferation drug effects
Cytokinesis drug effects
Dimethyl Sulfoxide
Female
Humans
Lymphocytes drug effects
Male
Micronucleus Tests
Plant Extracts chemistry
Plant Extracts isolation & purification
Rhodamines
Triterpenes chemistry
Triterpenes isolation & purification
Antineoplastic Agents toxicity
Asteraceae chemistry
Plant Extracts toxicity
Triterpenes toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 77
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 15979099
- Full Text :
- https://doi.org/10.1016/j.lfs.2005.05.024