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Surface-binding autoantibodies to cerebellar neurons in opsoclonus syndrome.

Authors :
Blaes F
Fühlhuber V
Korfei M
Tschernatsch M
Behnisch W
Rostasy K
Hero B
Kaps M
Preissner KT
Source :
Annals of neurology [Ann Neurol] 2005 Aug; Vol. 58 (2), pp. 313-7.
Publication Year :
2005

Abstract

Childhood opsoclonus-myoclonus syndrome can occur with or without associated neuroblastoma. An autoimmune pathogenesis has been discussed for both forms. We show here that the majority of children with opsoclonus-myoclonus syndrome (10/14) have autoantibodies binding to the surface of isolated rat cerebellar granular neurons. In some patients, these antibodies are masked by IgG binding to ubiquitous surface antigens, which could be removed by preincubation with the nonneuronal control cell line HEK 293. A newly introduced competitive binding assay showed that the surface binding is directed against the same autoantigen in different patients. Therefore, we hypothesize that opsoclonus-myoclonus syndrome may be the result of an autoimmune process against a neuronal surface protein.

Details

Language :
English
ISSN :
0364-5134
Volume :
58
Issue :
2
Database :
MEDLINE
Journal :
Annals of neurology
Publication Type :
Academic Journal
Accession number :
15988749
Full Text :
https://doi.org/10.1002/ana.20539