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Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Aug 15; Vol. 15 (16), pp. 3778-81. - Publication Year :
- 2005
-
Abstract
- The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines as potent kinase inhibitors are discussed.
- Subjects :
- Humans
Hydrogen Bonding
Molecular Structure
Protein Conformation
Protein Kinase Inhibitors chemistry
Protein Structure, Tertiary
Pyrimidines chemistry
Structure-Activity Relationship
Protein Kinase Inhibitors chemical synthesis
Protein Kinase Inhibitors pharmacology
Protein Kinases drug effects
Pyrimidines chemical synthesis
Pyrimidines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15993060
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.05.100