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Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny.
- Source :
-
Immunology [Immunology] 2005 Aug; Vol. 115 (4), pp. 544-55. - Publication Year :
- 2005
-
Abstract
- In this report, we describe 12 subpopulations of porcine gammadelta thymocytes based on their expression of CD1, CD2, CD4, CD8- isoforms and CD45RC. Our data suggest that gammadelta thymocytes can be divided into two major families: (a) one large family of CD4-gammadelta thymocytes that could be further subdivided according to the CD2/CD8alphaalpha phenotype and (b) a small family of CD4+ gammadelta thymocytes bearing CD8alphabeta and possessing certain unusual features in comparison with other gammadelta thymocytes. Maturation of gammadelta thymocytes within the CD4- family begins with proliferation of the CD2+ CD8- CD1+ CD45RC- gammadelta common precursor. This developmental stage is followed by diversification into the CD2+ CD8alphaalpha+, CD2+ CD8- and CD2- CD8- subsets. Their further maturation is accompanied by a loss of expression of CD1 and by increased expression of CD45RC. Therefore, individual subsets develop from CD1+ CD45RC- through CD1- CD45RC- into CD1- CD45RC+ cells. On the other hand, gammadelta thymocytes within the CD4+ family bear exclusively CD8alphabeta, always express CD1, but may coexpress CD45RC. These cells have no counterpart in the periphery. Our observations suggest that all peripheral CD8+ gammadelta T cells express CD8alphaalpha and that two subsets of these cells differing in major histocompatibility complex II expression, occur. We propose that one subset acquires CD8alphaalpha in the thymus while the second acquires CD8alphaalpha as a result of stimulation in the periphery.
- Subjects :
- Animals
Antigens, CD1 immunology
CD2 Antigens immunology
CD4-Positive T-Lymphocytes immunology
CD8 Antigens immunology
CD8-Positive T-Lymphocytes immunology
Cell Differentiation immunology
Cell Division immunology
Cells, Cultured
Histocompatibility Antigens Class II immunology
Immunophenotyping methods
Leukocyte Common Antigens immunology
Models, Animal
Spleen cytology
Spleen immunology
Swine
Thymus Gland cytology
Thymus Gland embryology
Thymus Gland immunology
Antigens, CD immunology
Receptors, Antigen, T-Cell, gamma-delta immunology
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-2805
- Volume :
- 115
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16011523
- Full Text :
- https://doi.org/10.1111/j.1365-2567.2005.02194.x