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Pulmonary sequelae of intraparenchymal bismuth subgallate.

Authors :
Cozzi LM
Megerian CA
Dugue C
Barcello M
Abdul-Karim FW
Arnold JE
Maniglia AJ
Source :
The Laryngoscope [Laryngoscope] 1992 Jun; Vol. 102 (6), pp. 597-9.
Publication Year :
1992

Abstract

Bismuth subgallate (BSG) is a heavy metal compound which is effective in lowering the incidence of hemorrhage after adenotonsillectomy and has been demonstrated to activate Factor XII. In a minority of children, the paste has been suctioned from the cuffless oral endotracheal tube after adenotonsillectomy. No pulmonary sequelae have been noted in these patients. To assess the effect of BSG aspiration, 75 rats were divided into groups receiving either intratracheal BSG or saline. Early and late parenchymal effects were documented at 5 and 30 days following administration. Although there were no differences in the general well-being, activity level, or weight in these rats, acute pneumonia followed by a histiocytic, foreign-body response was noted in a significant number of rats in the BSG group. Although no clinical pulmonary sequelae of BSG use have been noted in our patients, this information should alert clinicians to the risks of BSG use in the pulmonary-compromised patient, and encourage them to either employ all methods of preventing aspiration in such patients when using BSG, or to use another hemostatic modality for the utmost safety.

Details

Language :
English
ISSN :
0023-852X
Volume :
102
Issue :
6
Database :
MEDLINE
Journal :
The Laryngoscope
Publication Type :
Academic Journal
Accession number :
1602906
Full Text :
https://doi.org/10.1288/00005537-199206000-00001