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Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen determination.
- Source :
-
Urologia internationalis [Urol Int] 2005; Vol. 75 (1), pp. 57-61. - Publication Year :
- 2005
-
Abstract
- Introduction: We ascertained whether plasma chromogranin A enhances the power of serology assessing prostate cancer (PC).<br />Materials and Methods: We studied 56 PC and 83 benign prostatic hyperplasia (BPH) patients. In the sera we measured total prostate-specific antigen (tPSA) and free PSA (fPSA) and calculated the ratio between fPSA and tPSA (f/tPSA). In plasma samples the levels of chromogranin A (CgA) were also assayed.<br />Results: PC patients had higher CgA (p < 0.005) and tPSA (p < 0.05) levels, and a lower f/tPSA ratio (p < 0.001), than BPH patients. When f/tPSA and CgA were combined, the diagnostic sensitivity was enhanced (57-73%), while the specificity had only an 8% reduction (from 89 to 80%). CgA was only correlated to the Gleason PC score (p < 0.05).<br />Conclusions: CgA determination in PC may enhance the diagnostic accuracy of the f/tPSA assay and provides useful information on the tumor grade.<br /> (2005 S. Karger AG, Basel)
- Subjects :
- Aged
Aged, 80 and over
Biopsy
Carcinoma pathology
Carcinoma surgery
Chromogranin A
Enzyme-Linked Immunosorbent Assay
Humans
Male
Middle Aged
Neoplasm Staging
Prostatic Hyperplasia pathology
Prostatic Hyperplasia surgery
Prostatic Neoplasms pathology
Prostatic Neoplasms surgery
ROC Curve
Reproducibility of Results
Biomarkers, Tumor blood
Carcinoma blood
Chromogranins blood
Prostate-Specific Antigen blood
Prostatic Hyperplasia blood
Prostatic Neoplasms blood
Subjects
Details
- Language :
- English
- ISSN :
- 0042-1138
- Volume :
- 75
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Urologia internationalis
- Publication Type :
- Academic Journal
- Accession number :
- 16037709
- Full Text :
- https://doi.org/10.1159/000085929