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Synthesis and antitumor activity of fused quinoline derivatives. II. Novel 4- and 7-hydroxyindolo-[3,2-b]quinolines.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1992 Feb; Vol. 40 (2), pp. 528-30. - Publication Year :
- 1992
-
Abstract
- Novel indolo[3,2-b]quinoline derivatives (1c--f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) greater than 330%, cure = 5/6).
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Hydroxyquinolines chemistry
Hydroxyquinolines therapeutic use
Indoles chemistry
Indoles therapeutic use
Magnetic Resonance Spectroscopy
Mice
Antineoplastic Agents chemical synthesis
Hydroxyquinolines chemical synthesis
Indoles chemical synthesis
Leukemia P388 drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0009-2363
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 1606653
- Full Text :
- https://doi.org/10.1248/cpb.40.528