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Mechanisms of group B streptococcal-induced apoptosis of murine macrophages.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2005 Aug 15; Vol. 175 (4), pp. 2555-62. - Publication Year :
- 2005
-
Abstract
- Apoptosis of murine and human macrophages induced by group B Streptococcus agalactiae (GBS) is likely an important virulence mechanism that is used by the bacteria to suppress the host immune response and to persist at sites of infection. The mechanisms by which GBS induces apoptosis are, however, largely unknown. In this study, we report that in murine macrophages GBS induces unique changes in the regulation and localization of the apoptotic regulators Bad, 14-3-3, and Omi/high-temperature requirement A2 and leads to the release of cytochrome c and the activation of caspase-9 and caspase-3. Furthermore, inhibition of caspase-3 impaired GBS-induced apoptosis of macrophages. The ability to modulate the activity of effector caspases may therefore represent an unexploited avenue for therapeutic intervention in GBS infections.
- Subjects :
- 14-3-3 Proteins metabolism
14-3-3 Proteins physiology
Animals
Caspase 3
Caspase 9
Caspase Inhibitors
Caspases metabolism
Cell Line
Cytochromes c metabolism
Enzyme Activation
High-Temperature Requirement A Serine Peptidase 2
Macrophages enzymology
Macrophages, Peritoneal cytology
Macrophages, Peritoneal enzymology
Macrophages, Peritoneal metabolism
Macrophages, Peritoneal microbiology
Mice
Mice, Inbred C57BL
Mitochondria enzymology
Mitochondria metabolism
Mitochondria microbiology
Mitochondrial Proteins
Serine Endopeptidases metabolism
Serine Endopeptidases physiology
bcl-Associated Death Protein metabolism
bcl-Associated Death Protein physiology
Apoptosis immunology
Macrophages cytology
Macrophages microbiology
Streptococcus agalactiae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 175
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 16081829
- Full Text :
- https://doi.org/10.4049/jimmunol.175.4.2555