Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy in the management of advanced squamous cell carcinoma of the head and neck: a phase II trial.

Authors :: Merlano M
Russi EG
Numico G
Colantonio I
Garrone O
Pelissero A
Granetto C
Gasco M
Di Costanzo G
Heouaine A
Vigna Taglianti R
Cipolat M
Source :: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2005 May; Vol. 75 (2), pp. 193-6. Date of Electronic Publication: 2004 Dec 09.
Publication Year :: 2005
Abstract: Aim of the present study was to test, activity and toxicity of a rapidly alternating chemoradiation (paclitaxel based) in 31 patients with unresectable, locally advanced or recurrent after surgery, head and neck cancer. Three-year overall survival and progression-free survival were 61.4 and 73.7%, respectively. Main side effects remain a major problem.

Subjects :: Adult
Aged
Carcinoma, Squamous Cell pathology
Cisplatin administration & dosage
Combined Modality Therapy
Female
Fluorouracil administration & dosage
Head and Neck Neoplasms pathology
Humans
Male
Middle Aged
Paclitaxel administration & dosage
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell radiotherapy
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms radiotherapy

Language :: English
ISSN :: 0167-8140
Volume :: 75
Issue :: 2
Database :: MEDLINE
Journal :: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Publication Type :: Academic Journal
Accession number :: 16086909
Full Text :: https://doi.org/10.1016/j.radonc.2004.11.007

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