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Novel interactions of vitamin E and estrogen in breast cancer.
- Source :
-
Nutrition and cancer [Nutr Cancer] 2005; Vol. 52 (1), pp. 43-8. - Publication Year :
- 2005
-
Abstract
- The prevention of breast cancer through dietary modification is an active area of clinical and epidemiological research. It has been proposed that dietary supplementation of vitamin E may reduce a woman's risk of developing breast cancer. However, the exact mechanism remains unknown. alpha-Tocopherol is the most biologically active form of vitamin E. We investigated the effect of vitamin E (alpha-tocopherol) on breast cancer cell growth. A dose-dependent inhibition of cell proliferation was found in estrogen receptor (ER)-positive cells showing a potent suppression of growth at 100 microM vitamin E in MCF-7 (53%) and T47D (75%) cells. Vitamin E reduced significantly the response of both cell lines to estrogen (10 nM), and cell proliferation was decreased in MCF-7 and T47D cells by 69% and 84%, respectively. No growth inhibition was observed when cells were grown in the absence of estrogen. Vitamin E altered and decreased the growth inhibition induced by tamoxifen (10 microM) in MCF-7 (33%) and T47D (54%) cells. In addition, the immunostaining of ER of MCF-7 cells was reduced by 30% in the presence of vitamin E, suggesting an effect of vitamin E on the expression of ER. This provides evidence that vitamin E may inhibit ER-positive cell growth by altering the cellular response to estrogen.
- Subjects :
- Antineoplastic Agents, Hormonal antagonists & inhibitors
Breast Neoplasms epidemiology
Breast Neoplasms metabolism
Dietary Supplements
Dose-Response Relationship, Drug
Female
Humans
Tamoxifen antagonists & inhibitors
Tumor Cells, Cultured
Vitamin E pharmacology
Vitamins pharmacology
alpha-Tocopherol administration & dosage
alpha-Tocopherol pharmacology
Breast Neoplasms prevention & control
Cell Division drug effects
Estrogens metabolism
Receptors, Estrogen metabolism
Vitamin E administration & dosage
Vitamins administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0163-5581
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrition and cancer
- Publication Type :
- Academic Journal
- Accession number :
- 16091003
- Full Text :
- https://doi.org/10.1207/s15327914nc5201_6