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A common pathway for genetic events leading to pheochromocytoma.

Authors :
Maxwell PH
Source :
Cancer cell [Cancer Cell] 2005 Aug; Vol. 8 (2), pp. 91-3.
Publication Year :
2005

Abstract

Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.

Subjects

Subjects :
Apoptosis
Dioxygenases
Down-Regulation
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Hypoxia-Inducible Factor-Proline Dioxygenases
Mutation
Procollagen-Proline Dioxygenase genetics
Adrenal Gland Neoplasms enzymology
Adrenal Gland Neoplasms genetics
Pheochromocytoma enzymology
Pheochromocytoma genetics
Procollagen-Proline Dioxygenase metabolism

Details

Language :
English
ISSN :
1535-6108
Volume :
8
Issue :
2
Database :
MEDLINE
Journal :
Cancer cell
Publication Type :
Academic Journal
Accession number :
16098460
Full Text :
https://doi.org/10.1016/j.ccr.2005.07.012
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