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Analysis of recombinant group B streptococcal protein ScaAB and evaluation of its immunogenicity.
- Source :
-
Folia microbiologica [Folia Microbiol (Praha)] 2005; Vol. 50 (2), pp. 172-6. - Publication Year :
- 2005
-
Abstract
- Group B streptococcal (GBS) gene encoding the putative lipoprotein and adherence factor ScaAB was cloned and expressed in E. coli. Recombinant ScaAB protein was isolated. Signal sequence of ScaAB was found to be cleaved in the E. coli host. ScaAB recombinant protein was immunogenic in mice and antibodies against this protein were discovered in mice sera after GBS infection. The perspectives of the use of ScaAB protein in GBS vaccine are discussed.
- Subjects :
- Amino Acid Sequence
Animals
Antibodies, Bacterial blood
Bacterial Adhesion
Bacterial Proteins chemistry
Bacterial Proteins genetics
Bacterial Proteins metabolism
Immunization
Membrane Proteins chemistry
Membrane Proteins genetics
Membrane Proteins metabolism
Mice
Molecular Sequence Data
Recombinant Proteins chemistry
Recombinant Proteins genetics
Recombinant Proteins metabolism
Streptococcal Infections microbiology
Streptococcal Infections mortality
Streptococcus agalactiae isolation & purification
Streptococcus agalactiae pathogenicity
Bacterial Proteins immunology
Membrane Proteins immunology
Recombinant Proteins immunology
Streptococcal Infections prevention & control
Streptococcus agalactiae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0015-5632
- Volume :
- 50
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Folia microbiologica
- Publication Type :
- Academic Journal
- Accession number :
- 16110924
- Full Text :
- https://doi.org/10.1007/BF02931468