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Activity of antimicrobial agents against Mycobacterium avium-intracellulare complex (MAC) strains isolated in Italy from AIDS-patients.
- Source :
-
Zentralblatt fur Bakteriologie : international journal of medical microbiology [Zentralbl Bakteriol] 1992 Apr; Vol. 276 (4), pp. 512-20. - Publication Year :
- 1992
-
Abstract
- Twenty-five strains of Mycobacterium avium-intracellulare (MAC) isolated from acquired immunodeficiency syndrome (AIDS) patients in three medical centres in Italy have been studied. Serotyping performed on eighteen strains showed various serovars within either M. avium or M. intracellulare serotypes and with serovars 1 and 21 being the most prevalent (four strains for each serovar). Among fourteen drugs used for testing the antibiotic sensitivity, rifapentine, rifabutin and clofazimine showed to have the best in vitro activity. In an ex vivo model of infection using peritoneal resting macrophages from the C57BL/6 mouse, the intracellular viability of a strain of M. avium (strain 489, serovar 3) was reduced by clofazimine, amikacin, ciprofloxacin, rifabutin and clarithromycin (99, 98, 93, 89 and 69%, respectively), thus indicating for clofazimine a good correlation between in vitro and ex vivo activity.
- Subjects :
- Animals
Cells, Cultured
Humans
Italy
Macrophages drug effects
Mice
Mycobacterium avium-intracellulare Infection complications
Acquired Immunodeficiency Syndrome complications
Anti-Bacterial Agents pharmacology
Macrophages microbiology
Mycobacterium avium Complex drug effects
Mycobacterium avium-intracellulare Infection microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0934-8840
- Volume :
- 276
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zentralblatt fur Bakteriologie : international journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 1611208