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Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.
Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.
- Source :
-
Journal of cutaneous pathology [J Cutan Pathol] 2005 Sep; Vol. 32 (8), pp. 572-6. - Publication Year :
- 2005
-
Abstract
- Background: Plexiform fibrohistiocytic tumor is a soft-tissue tumor of intermediate malignancy occurring in children and young adults but is only rarely found in infants. The tumor usually involves the upper limbs and is slow growing and painless. Recurrence rate is high. Lymph node and systemic metastases can occur, but have never been reported in infants. Clinical behavior in infancy is not known. Histologically, the tumor is characterized by nodules of histiocyte-like and multinucleated cells and fascicles of spindle cells arranged in a plexiform pattern. Mitosis, atypia, and nuclear pleomorphism are common but not pronounced.<br />Methods and Results: We report three cases in infants, one of which is congenital, having an unusual topography and a broad histological spectrum.<br />Conclusion: In infants, wide excision with large safety margins should be performed as the behaviour of this tumor remains uncertain. Leclerc S, Hamel-Teillac D, Oger P, Brousse N, Fraitag S. Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.
- Subjects :
- Biomarkers, Tumor analysis
Female
Histiocytoma, Benign Fibrous chemistry
Histiocytoma, Benign Fibrous surgery
Humans
Immunoenzyme Techniques
Infant
Male
Soft Tissue Neoplasms chemistry
Soft Tissue Neoplasms surgery
Treatment Outcome
Histiocytoma, Benign Fibrous pathology
Soft Tissue Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0303-6987
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of cutaneous pathology
- Publication Type :
- Academic Journal
- Accession number :
- 16115057
- Full Text :
- https://doi.org/10.1111/j.0303-6987.2005.00334.x