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No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study.
- Source :
-
BMC medical genetics [BMC Med Genet] 2005 Sep 05; Vol. 6, pp. 31. Date of Electronic Publication: 2005 Sep 05. - Publication Year :
- 2005
-
Abstract
- Background: Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent and highly heritable childhood disorder. The dopamine D4 receptor (DRD4) gene has shown a genetic association with ADHD in Caucasian populations with meta-analysis indicating a small but significant effect across datasets. It remains uncertain whether this association can be generalised to non-Caucasian ethnic groups. Here we investigate two markers within the DRD4 gene in a Taiwanese population, the exon 3 variable number tandem repeat (VNTR) and a 5' 120 base-pair duplication.<br />Methods: Within-family transmission disequilibrium tests of association of the 5' 120 base-pair duplication, and exon 3 VNTR in a Taiwanese population.<br />Results: No evidence of association of ADHD with either polymorphism in this population was observed.<br />Conclusion: The DRD4 gene markers investigated were not found to be associated with ADHD in this Taiwanese sample. Further work in Taiwanese and other Asian populations will therefore be required to establish whether the reports of association of DRD4 genetic variants in Caucasian samples can be generalised to Asian populations.
- Subjects :
- Adolescent
Attention Deficit Disorder with Hyperactivity ethnology
Child
Child, Preschool
Family Health
Gene Frequency
Humans
Receptors, Dopamine D4
Taiwan
Tandem Repeat Sequences
Attention Deficit Disorder with Hyperactivity genetics
Genetic Predisposition to Disease
Polymorphism, Genetic
Receptors, Dopamine D2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2350
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- BMC medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 16143039
- Full Text :
- https://doi.org/10.1186/1471-2350-6-31