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The pathophysiology of the growth plate in juvenile idiopathic arthritis.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2006 Jan; Vol. 45 (1), pp. 11-9. Date of Electronic Publication: 2005 Sep 07. - Publication Year :
- 2006
-
Abstract
- Children with chronic inflammatory diseases, such as juvenile idiopathic arthritis (JIA), suffer from a variety of growth disorders. These range from general growth retardation to local acceleration of growth in the affected limb. These disorders are associated with the increased production of proinflammatory cytokines, which may influence growth through a local effect in the growth plates of long bones and/or systemic effects throughout the whole body. In this article we review these aspects and also discuss the evidence for interaction between the inflammatory cytokine and growth-signalling pathways.
Details
- Language :
- English
- ISSN :
- 1462-0324
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 16148018
- Full Text :
- https://doi.org/10.1093/rheumatology/kei091