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Effects of copper on A-type potassium currents in acutely dissociated rat hippocampal CA1 neurons.
- Source :
-
Neuroreport [Neuroreport] 2005 Sep 28; Vol. 16 (14), pp. 1585-9. - Publication Year :
- 2005
-
Abstract
- The effects of copper on voltage-gated A-type potassium currents were investigated in acutely dissociated rat hippocampal CA1 neurons using the whole-cell patch-clamp technique. Extracellular application of various concentrations of copper (1-1000 microM) reversibly reduced the amplitude of voltage-gated A-type potassium currents in a dose-dependent manner with a 50% inhibitory concentration value of 130 microM. Copper (300 microM) increased the V1/2 of the activation curve and state-inactivation curve by 17.2 and 9.0 mV, respectively. Thus, copper slowed down the activation and inactivation process of voltage-gated A-type potassium currents. This study indicated that copper reversibly inhibits the hippocampal CA1 neuronal voltage-gated A-type potassium current in a dose-dependent and voltage-dependent manner, and such actions are likely involved in the regulation of the neuronal excitability and the pathophysiology of Wilson's disease.
- Subjects :
- Animals
Animals, Newborn
Dose-Response Relationship, Drug
Electric Stimulation methods
Membrane Potentials drug effects
Membrane Potentials physiology
Membrane Potentials radiation effects
Neurons physiology
Neurons radiation effects
Patch-Clamp Techniques methods
Potassium Channels, Voltage-Gated drug effects
Rats
Rats, Wistar
Copper pharmacology
Hippocampus cytology
Neurons drug effects
Potassium Channels, Voltage-Gated physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 16
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 16148750
- Full Text :
- https://doi.org/10.1097/01.wnr.0000181578.72894.b9