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Cortical neuronal densities and lamination in focal cortical dysplasia.
- Source :
-
Acta neuropathologica [Acta Neuropathol] 2005 Oct; Vol. 110 (4), pp. 383-92. Date of Electronic Publication: 2005 Sep 07. - Publication Year :
- 2005
-
Abstract
- Focal cortical dysplasia (FCD) is considered to represent a malformation due to abnormal cortical development (MCD) and is an important cause of focal epilepsy. The histopathological features include abnormal laminar architecture, the presence of hypertrophic and dysmorphic neurones in FCD type IIA and additional balloon cells in FCD type IIB. The events causing these sporadic lesions are unknown, but abnormal progenitor cell proliferation occurring late in corticogenesis has been proposed. FCD-like lesions have, however, also been described following a cerebral injury early in life. We carried out a stereological assessment on 15 cases of FCD on NeuN- and Nissl-stained sections from patients with a wide age range, and identified a significant reduction in the neuronal density in all cases in the region of dysplasia compared to the adjacent unaffected cortex (mean neuronal densities 19.2x10(3)/mm3 in the region of dysplasia; 42.8x10(3)/mm3 in the adjacent cortex). Relative differences in neuronal density and size in FCD cases between the superficial (layer I and II) and deep cortical laminae (layer V and VI) were similar to that observed in other pathologies including mild MCD, temporal neocortex adjacent to hippocampal sclerosis as well as in a non-epilepsy surgical control group. The lower overall neuronal densities observed in FCD may reflect neuropil expansion, a local failure of neuronal migration, proliferation or secondary neuronal loss. The preservation of relative differences in neuronal densities between cortical layers and laminar patterns of neurofilament staining in FCD would support the view that the temporal sequence of lamination is not affected.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Cell Count methods
Cell Proliferation
Cerebral Cortex metabolism
Child
Child, Preschool
Female
Humans
Infant
Male
Middle Aged
Nervous System Malformations metabolism
Neurofilament Proteins metabolism
Neurons metabolism
Phosphopyruvate Hydratase metabolism
Cerebral Cortex pathology
Nervous System Malformations pathology
Neurons pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6322
- Volume :
- 110
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 16151726
- Full Text :
- https://doi.org/10.1007/s00401-005-1062-0