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Italian multicentric pilot study on MBL2 genetic polymorphisms in HIV positive pregnant women and their children.
- Source :
-
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2005 Apr; Vol. 17 (4), pp. 253-6. - Publication Year :
- 2005
-
Abstract
- Objective: We investigated genetic polymorphisms of MBL2 gene, in a cohort of 90 Italian HIV-1 pregnant seropositive women and their children in order to understand whether the MBL2 genotype of HIV-1 positive mothers might be related to their ability to transmit the virus to their children.<br />Materials and Methods: DNA was extracted from Iso Code Stix cards, and MBL2 genotyping was performed by Melting Temperature Assay.<br />Results: The frequency of the MBL2 0/0 homozygotes was higher in HIV-1 positive mothers than in healthy controls, the MBL2 0/0 genotype was more frequent in children born from HIV positive mothers than healthy subjects.<br />Conclusions: We have confirmed the association of polymorphisms involving a gene of the innate immunity with an increased risk of being infected by HIV. These polymorphisms were also evidenced in children born from HIV+ mothers, but the risk of infection was strongly reduced by cesarean delivery and by antiretroviral treatment.
- Subjects :
- Adult
Cohort Studies
Female
Genetic Predisposition to Disease
HIV Infections immunology
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Italy
Male
Pilot Projects
Polymorphism, Genetic
Pregnancy
HIV Infections transmission
HIV-1
Immunity, Innate genetics
Mannose-Binding Lectin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-7058
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Publication Type :
- Academic Journal
- Accession number :
- 16152689
- Full Text :
- https://doi.org/10.1080/14767050500072599