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The role of hepatitis C virus (HCV) in mitochondrial DNA damage in HIV/HCV-coinfected individuals.
- Source :
-
Antiviral therapy [Antivir Ther] 2005; Vol. 10 Suppl 2, pp. M109-15. - Publication Year :
- 2005
-
Abstract
- Oxidative stress accompanying hepatitis C virus (HCV) infection seems to result in mitochondrial (mt) dysfunction. In HIV/HCV-coinfected individuals, HCV-related mt damage could be further enhanced and clinical manifestations of mt damage may appear, particularly following exposure to some antiretroviral drugs. Furthermore, when HCV medications are used together with certain antiretrovirals, the risk of developing mt adverse events may be particularly frequent, such as development of pancreatitis when ribavirin and didanosine are coadministered. The management of HIV/HCV-coinfected individuals needs to consider the high risk of mitochondria-associated toxicities in this population, which may significantly influence treatment decisions and therapeutic modalities.
- Subjects :
- Acidosis, Lactic etiology
Anti-HIV Agents adverse effects
Antiviral Agents adverse effects
HIV Infections drug therapy
HIV-Associated Lipodystrophy Syndrome etiology
Hepatitis C drug therapy
Humans
Lactic Acid blood
Liver drug effects
DNA Damage
DNA, Mitochondrial analysis
HIV Infections complications
Hepatitis C complications
Subjects
Details
- Language :
- English
- ISSN :
- 1359-6535
- Volume :
- 10 Suppl 2
- Database :
- MEDLINE
- Journal :
- Antiviral therapy
- Publication Type :
- Academic Journal
- Accession number :
- 16152712