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No association between ACE I/D polymorphism and cardiovascular hemodynamics during exercise in young women.

Authors :
Roltsch MH
Brown MD
Hand BD
Kostek MC
Phares DA
Huberty A
Douglass LW
Ferrell RE
Hagberg JM
Source :
International journal of sports medicine [Int J Sports Med] 2005 Oct; Vol. 26 (8), pp. 638-44.
Publication Year :
2005

Abstract

The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO2), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O2 diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18-35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO2max (II 41.4+/-1.2, ID 39.8+/-0.9, DD 39.8+/-1.1 ml/kg/min, p=ns) or maximal HR (II 191+/-2, ID 191+/-1, DD 193+/-2 bpm, p=ns). In addition, systolic and diastolic BP, (a-v)O2 diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O2 diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p=0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women.

Details

Language :
English
ISSN :
0172-4622
Volume :
26
Issue :
8
Database :
MEDLINE
Journal :
International journal of sports medicine
Publication Type :
Academic Journal
Accession number :
16158368
Full Text :
https://doi.org/10.1055/s-2004-830436