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[Expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma].
- Source :
-
Ai zheng = Aizheng = Chinese journal of cancer [Ai Zheng] 2005 Sep; Vol. 24 (9), pp. 1136-9. - Publication Year :
- 2005
-
Abstract
- Background & Objective: Vascular endothelial growth factor-C and -D (VEGF-C, VEGF-D) are related to lymphangiogenesis. Papillary thyroid carcinoma is characterized by regional lymph node metastasis. This study was designed to determine the expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma.<br />Methods: The expression of VEGF, VEGF-C, and VEGF-D in 115 specimens of papillary thyroid carcinoma and 20 specimens of nodular goiter were detected by SP immunohistochemistry.<br />Results: Positive rates of VEGF, VEGF-C, and VEGF-D were significantly higher in papillary thyroid carcinoma than in nodular goiter (79.1% vs. 30.0%, 87.0% vs. 15.0%, and 72.2% vs. 20.0%, P<0.01). The expression of VEGF was closely related to the size of papillary thyroid carcinoma. Positive rates of VEGF were 84.7% in lymph node positive group, and 73.2% in lymph node negative group. Positive rates of VEGF-C and VEGF-D were significantly higher in lymph node positive group than in lymph node negative group (93.2% vs. 80.4%, P<0.05; 83.1% vs. 60.7%, P<0.01).<br />Conclusion: VEGF is closely related to tumor growth of papillary thyroid carcinoma; while VEGF-C and VEGF-D are closely related to lymph node metastasis of papillary thyroid carcinoma, and may be predictors of lymph node metastasis.
- Subjects :
- Adult
Biomarkers, Tumor
Carcinoma, Papillary pathology
Cytoplasm metabolism
Female
Humans
Lymphatic Metastasis
Male
Thyroid Neoplasms pathology
Carcinoma, Papillary metabolism
Thyroid Neoplasms metabolism
Vascular Endothelial Growth Factor A metabolism
Vascular Endothelial Growth Factor C metabolism
Vascular Endothelial Growth Factor D metabolism
Subjects
Details
- Language :
- Chinese
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Ai zheng = Aizheng = Chinese journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 16159441