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Synthesis and cytotoxicity of new potential intercalators based on tricyclic systems of some pyrimido[5,4-c]cinnoline and pyrimido[5,4-c]quinoline derivatives. Part I.
- Source :
-
Acta poloniae pharmaceutica [Acta Pol Pharm] 2005 Mar-Apr; Vol. 62 (2), pp. 105-10. - Publication Year :
- 2005
-
Abstract
- Pyrimido[5,4-c]cinnoline and pyrimido[5,4-c]quinoline derivatives have been tested as potential intercalators. All of them embody stuctural properties alike to afford intercalating activity. Their cytotoxicity was determined on the two human leukemia cell lines, the promyelocytic HL-60 and the lymphoblastic NALM-6. The viability of cells exposed continuously to tested compounds was estimated by the trypan-blue exclusion assay. IC50 data for the NALM-6 cell line are lower than for the HL-60 cell line, what suggested that the HL-60 leukemia cells are more resistant to toxic action of tested compounds. All compounds exerted moderate cytotoxic activity. The compounds were analyzed with the HyperChem/ChemPlus software trying to find basic structure-activity relationships.
- Subjects :
- Bridged-Ring Compounds classification
Bridged-Ring Compounds pharmacology
Cell Survival drug effects
HL-60 Cells
Heterocyclic Compounds, 2-Ring chemical synthesis
Heterocyclic Compounds, 2-Ring pharmacology
Heterocyclic Compounds, 3-Ring pharmacology
Humans
Inhibitory Concentration 50
Intercalating Agents pharmacology
Pyridazines chemical synthesis
Pyridazines pharmacology
Pyrimidines pharmacology
Quantitative Structure-Activity Relationship
Quinolines chemical synthesis
Quinolines pharmacology
Bridged-Ring Compounds chemical synthesis
Heterocyclic Compounds, 3-Ring chemical synthesis
Intercalating Agents chemical synthesis
Pyrimidines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6837
- Volume :
- 62
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta poloniae pharmaceutica
- Publication Type :
- Academic Journal
- Accession number :
- 16161350