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Analysis of outcome of laparoscopic splenectomy for idiopathic thrombocytopenic purpura by platelet count.

Authors :
Keidar A
Feldman M
Szold A
Source :
American journal of hematology [Am J Hematol] 2005 Oct; Vol. 80 (2), pp. 95-100.
Publication Year :
2005

Abstract

Laparoscopic splenectomy (LS) is now performed routinely in patients with idiopathic thrombocytopenic purpura (ITP) refractory to the medical treatment. Low preoperative platelet count was deemed to be a contraindication for a laparoscopic approach; however, there is no data reporting the outcome in those patients. We aimed to evaluate the influence of the preoperative platelet count on the operative and postoperative course and complication rate. Retrospective cohort study that was conducted in tertiary care university-affiliated medical center and included 110 consecutive patients who underwent LS. All patients were divided into three groups by their preoperative platelet counts: <or=20 x 10(9)/L (n = 12), (20-50) x 10(9)/L (n = 18), and >50 x 10(9)/L (n = 80). The outcome and the influence of preoperative factors predictive of complications, blood transfusion, and length of stay were compared between the groups. Patients with a platelet count of <or=20 x 10(9)/L had a much longer hospital stay, received more blood transfusions, and suffered more complications than patients with platelet counts of (20-50) x 10(9)/L or higher (P < 0.05). Transfused patients had a longer hospital stay than non-transfused patients (2.08 vs. 6.4 days, P = 0.029). The strongest predictor for transfusion was the platelet count (odds ratio = 23, P = 0.008). LS in patients with very low platelet counts is feasible and reasonably safe, but the platelet count is a major determinant of morbidity. Every effort should be made to elevate platelet levels to >20 x 10(9)/L before surgery. Patients with counts >20 x 10(9)/L can safely undergo LS.<br /> ((c) 2005 Wiley-Liss, Inc.)

Details

Language :
English
ISSN :
0361-8609
Volume :
80
Issue :
2
Database :
MEDLINE
Journal :
American journal of hematology
Publication Type :
Academic Journal
Accession number :
16184593
Full Text :
https://doi.org/10.1002/ajh.20433