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Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.

Authors :
Blizzard TA
Morgan JD 2nd
Chan W
Birzin ET
Pai LY
Hayes EC
DaSilva CA
Mosley RT
Yang YT
Rohrer SP
Dininno F
Hammond ML
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Dec 01; Vol. 15 (23), pp. 5124-8. Date of Electronic Publication: 2005 Oct 03.
Publication Year :
2005

Abstract

Two novel side chains which had previously been found to enhance antagonist activity in the dihydrobenzoxathiin SERM series were applied to three existing platforms. The novel side chains did not improve the antagonist activity of the existing platforms.

Details

Language :
English
ISSN :
0960-894X
Volume :
15
Issue :
23
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
16203138
Full Text :
https://doi.org/10.1016/j.bmcl.2005.08.084