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Effect of a 24-hour infusion of an isotonic electrolyte replacement fluid on the renal clearance of electrolytes in healthy neonatal foals.

Authors :
Buchanan BR
Sommardahl CS
Rohrbach BW
Andrews FM
Source :
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2005 Oct 01; Vol. 227 (7), pp. 1123-9.
Publication Year :
2005

Abstract

Objective: To determine the effects of a 24-hour infusion of an isotonic electrolyte replacement fluid (IERF) on weight, serum and urine electrolyte concentrations, and other clinicopathologic variables in healthy neonatal foals.<br />Animals: 4 healthy 4-day-old foals.<br />Design: Prospective study.<br />Procedure: An IERF was administered to each foal at an estimated rate of 80 mL/kg/d (36.4 mL/lb/d) for 24 hours. Body weight was measured before and after the infusion period. Urine was collected via catheter during 4-hour periods; blood samples were collected at 4-hour intervals. Variables including urine production; urine and serum osmolalities; sodium, potassium, and chloride concentrations in urine and serum; urine and serum creatinine concentrations; urine osmolality-to-serum osmolality ratio (OsmR); transtubular potassium gradient (TTKG); and percentage creatinine clearance (Cr(cl)) of electrolytes were recorded at 0, 4, 8, 12, 16, 20, and 24 hours during the infusion period. Immediately after the study period, net fluid and whole-body electrolyte changes from baseline values were calculated.<br />Results: Compared with baseline values, urine and serum sodium and chloride serum concentrations, urine and serum osmolalities, OsmR, and percentage Cr(cl) of sodium and chloride were significantly increased at various time points during the infusion; urine production did not change significantly. After 24 hours, weight, TTKG, serum creatinine concentration, and whole-body potassium had significantly decreased from baseline values.<br />Conclusions and Clinical Relevance: Results suggest that administration of an IERF containing a physiologic concentration of sodium may not be appropriate for use in neonatal foals that require maintenance fluid therapy.

Details

Language :
English
ISSN :
0003-1488
Volume :
227
Issue :
7
Database :
MEDLINE
Journal :
Journal of the American Veterinary Medical Association
Publication Type :
Academic Journal
Accession number :
16220674
Full Text :
https://doi.org/10.2460/javma.2005.227.1123