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A combined approach for locating box H/ACA snoRNAs in the human genome.
- Source :
-
Molecules and cells [Mol Cells] 2005 Aug 31; Vol. 20 (1), pp. 35-42. - Publication Year :
- 2005
-
Abstract
- A novel combined method for locating box H/ACA small nucleolar RNAs (snoRNAs) is described, together with a software tool. The method adopts both a probabilistic hidden Markov model (HMM) and a minimum free energy (MFE) rule, and filters possible candidate box H/ACA snoRNAs obtained from genomic DNA sequences. With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences.
Details
- Language :
- English
- ISSN :
- 1016-8478
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecules and cells
- Publication Type :
- Academic Journal
- Accession number :
- 16258239