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Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2005 Nov 15; Vol. 175 (10), pp. 6265-70. - Publication Year :
- 2005
-
Abstract
- Unlike graft-resident donor-derived hemopoietic APCs, which decrease in number over time after transplantation, vascular endothelial cells are lifelong residents of a vascularized allograft. Endothelial cells are potent APCs for allogeneic CD8+ T lymphocytes but are unable to induce proliferation of allogeneic CD4+ T lymphocytes. Although the reason for this differential response has been poorly understood, here we report that alloantigen presentation by vascular endothelium to CD4+ T lymphocytes activates and induces CD4+25+Foxp3+ regulatory T cells, which can inhibit proliferation of alloreactive T cells both in vitro and in vivo. This process occurs independently of B7.1 costimulation but is dependent on programmed death ligand 1 (B7-H1). This finding may have important implications for tolerance induction in transplantation.
- Subjects :
- Animals
CD4-Positive T-Lymphocytes metabolism
Coculture Techniques
Forkhead Transcription Factors metabolism
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Knockout
Receptors, Interleukin-2 metabolism
T-Lymphocyte Subsets metabolism
Transplantation, Homologous
CD4-Positive T-Lymphocytes immunology
Endothelium, Vascular immunology
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 175
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 16272276
- Full Text :
- https://doi.org/10.4049/jimmunol.175.10.6265