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Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy.

Authors :
Sugimoto M
Sasoh M
Ido M
Wakitani Y
Takahashi C
Uji Y
Source :
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde [Ophthalmologica] 2005 Nov-Dec; Vol. 219 (6), pp. 379-85.
Publication Year :
2005

Abstract

Purpose: To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test.<br />Methods: Thirty-two patients with NDR (n = 32) were enrolled. We examined retinal and retinal nerve fiber layer (RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness (n = 48) and RNFL thickness (n = 34). Both OCT measurements were obtained in four areas (temporal, superior, nasal and inferior). The receiver operator characteristic (ROC) curve was generated to evaluate the predictor variables.<br />Results: Comparing the normal and NDR eyes, retinal thickness significantly increased (p = 0.03) and RNFL thickness significantly decreased (p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness.<br />Conclusions: Both OCT measurements can detect early retinal damage in NDR patients.<br /> (Copyright 2005 S. Karger AG, Basel.)

Details

Language :
English
ISSN :
0030-3755
Volume :
219
Issue :
6
Database :
MEDLINE
Journal :
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
Publication Type :
Academic Journal
Accession number :
16286799
Full Text :
https://doi.org/10.1159/000088382