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TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2005 Dec 30; Vol. 338 (4), pp. 1745-50. Date of Electronic Publication: 2005 Nov 02. - Publication Year :
- 2005
-
Abstract
- Apoptosis has been attributed an essential role in dilated cardiomyopathy (DCM) recently. We assessed expression of TNF-related apoptosis-inducing ligand (TRAIL) and its decoy receptor osteoprotegerin (OPG) in men with nonischemic DCM, who underwent coronary angiography and endomyocardial biopsy (EMB) after exclusion of coronary artery disease compared to control patients. TRAIL plasma concentrations were elevated in DCM (p=0.02 vs. controls), and were positively correlated with left ventricular enddiastolic diameter (r=0.15, p=0.04), whereas OPG plasma levels did not differ between both groups (p=0.96). In EMB of DCM patients, TRAIL and OPG protein were detected by immunohistochemistry but not in controls. Furthermore, gene expression in EMB or peripheral blood leukocytes (PBL) of DCM patients assessed by real-time PCR showed an increase of TRAIL mRNA in PBL (p=0.01 vs. controls), whereas OPG mRNA was upregulated in endomyocardial specimens (p<0.001 vs. controls). In conclusion, myocardial overexpression of antiapoptotic OPG in DCM patients may represent a compensatory mechanism to limit systemic activation of TRAIL in patients with congestive heart disease.
- Subjects :
- Adult
Biopsy
Fetal Heart metabolism
Gene Expression Regulation
Humans
Male
Middle Aged
Myocardium metabolism
Osteoprotegerin
TNF-Related Apoptosis-Inducing Ligand
Up-Regulation
Ventricular Dysfunction, Left physiopathology
Apoptosis Regulatory Proteins biosynthesis
Cardiomyopathy, Dilated physiopathology
Glycoproteins biosynthesis
Membrane Glycoproteins biosynthesis
Receptors, Cytoplasmic and Nuclear biosynthesis
Receptors, Tumor Necrosis Factor biosynthesis
Tumor Necrosis Factor-alpha biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 338
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 16288714
- Full Text :
- https://doi.org/10.1016/j.bbrc.2005.10.136