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Investigation of central versus peripheral effects of estradiol in ovariectomized mice.
- Source :
-
The Journal of endocrinology [J Endocrinol] 2005 Nov; Vol. 187 (2), pp. 303-9. - Publication Year :
- 2005
-
Abstract
- It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariectomized (ovx) mice. The dose-response curves for central and peripheral E2 administration did not differ for any of the studied estrogen-responsive tissues, indicating that these effects were mainly peripheral. In addition, ovx mice were treated with E2 and/or the peripheral estrogen receptor antagonist ICI 182,780. ICI 182,780 attenuated most of the estrogenic response regarding uterus weight, retroperitoneal fat weight, cortical BMC and trabecular bone mineral content (P<0.05). These findings support the notion that the primary target tissue that mediates the effect of E2 on bone is peripheral and not central.
- Subjects :
- Animals
Bone Density
Dose-Response Relationship, Drug
Drug Implants
Estradiol analogs & derivatives
Estradiol pharmacology
Estrogen Antagonists pharmacology
Female
Femur drug effects
Femur physiopathology
Fulvestrant
Humans
Mice
Mice, Inbred C57BL
Middle Aged
Models, Animal
Osteoporosis, Postmenopausal physiopathology
Ovariectomy
Tibia drug effects
Tibia physiopathology
Tomography, X-Ray Computed
Bone and Bones drug effects
Brain drug effects
Estradiol administration & dosage
Osteoporosis, Postmenopausal metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-0795
- Volume :
- 187
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 16293778
- Full Text :
- https://doi.org/10.1677/joe.1.06181