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Antitumor effects of synthetic VEGF-receptor binding antagonist, VGA1155.
- Source :
-
Anticancer research [Anticancer Res] 2005 Nov-Dec; Vol. 25 (6B), pp. 3973-7. - Publication Year :
- 2005
-
Abstract
- Vascular endothelial growth factor (VEGF) plays key roles in tumor angiogenesis. Therefore, VEGF and its receptors are considered to be primary targets for antiangiogenic strategy during cancer chemotherapy. Our previous study reported that VGA1155, a low-molecular-weight inhibitor of the binding of VEGF, inhibited VEGF binding to KDR/Flk-1 receptor-overexpressing cells. In the present study, the antitumor effects and antimetastatic effect of VGA1155 were examined in vivo. VGA1155 suppressed the growth of human lung, breast, colon and epidermoid cancers (LC-6, HT29, MX-1, Col-1 and A431) in the nude mouse xenograft model, and pulmonary metastasis of melanoma in the spontaneous metastasis model. These results suggest that VGA1155 has antitumor effects in vivo through the inhibition of VEGF binding to its receptors.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Breast Neoplasms blood supply
Breast Neoplasms drug therapy
Breast Neoplasms pathology
Carcinoma, Non-Small-Cell Lung blood supply
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Squamous Cell blood supply
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell pathology
Cell Growth Processes drug effects
Colonic Neoplasms blood supply
Colonic Neoplasms drug therapy
Colonic Neoplasms pathology
Humans
Lung Neoplasms blood supply
Lung Neoplasms drug therapy
Lung Neoplasms pathology
Melanoma, Experimental blood supply
Melanoma, Experimental drug therapy
Melanoma, Experimental pathology
Mice
Mice, Inbred BALB C
Mice, Nude
Neovascularization, Pathologic drug therapy
Receptors, Vascular Endothelial Growth Factor metabolism
Vascular Endothelial Growth Factor A metabolism
Xenograft Model Antitumor Assays
Benzoates pharmacology
Receptors, Vascular Endothelial Growth Factor antagonists & inhibitors
Vascular Endothelial Growth Factor A antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 25
- Issue :
- 6B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 16309186