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Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.
- Source :
-
Anticancer research [Anticancer Res] 2005 Nov-Dec; Vol. 25 (6B), pp. 3825-31. - Publication Year :
- 2005
-
Abstract
- Background: Local delivery of carmustine (BCNU) via biodegradable polymers has been shown to improve survival in patients with glioblastoma multiforme (GBM). In the current study, we hypothesized that local delivery of an anthracycline antibiotic, doxorubicin (DOX), might act to improve the survival of animals bearing experimental intracranial glioma.<br />Materials and Methods: Polyanhydride polymers (PCPP-SA), containing either 3% or 5% ADR by weight, were prepared using the mix-melt method. Forty male Fisher 344 rats received an intracranial challenge with a lethal dose of 9L gliosarcoma cells. Five days later, they received DOX or blank polymer. There were a total of four treatment groups: (1) blank polymer; (2) 3% DOX polymer; (3) 5% DOX polymer, and (4) control group with no polymer.<br />Results: Compared to control animals treated with no polymers or blank polymer, animals receiving DOX had significantly extended survival. The median survival for the control group was 21 days vs. 34 days (p < 0.01) for the 3% DOX group and 45 days (p < 0.0001) for the 5% DOX group.<br />Conclusion: Doxorubicin, when delivered locally, is an effective monotherapeutic agent against experimental intracranial glioma.
- Subjects :
- Animals
Antibiotics, Antineoplastic toxicity
Biocompatible Materials administration & dosage
Biocompatible Materials toxicity
Brain Neoplasms pathology
Cell Line, Tumor
Decanoic Acids toxicity
Delayed-Action Preparations
Doxorubicin toxicity
Drug Carriers administration & dosage
Drug Carriers toxicity
Drug Implants
Female
Gliosarcoma pathology
Polyesters toxicity
Rats
Rats, Inbred F344
Antibiotics, Antineoplastic administration & dosage
Brain Neoplasms drug therapy
Decanoic Acids administration & dosage
Doxorubicin administration & dosage
Gliosarcoma drug therapy
Polyesters administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 25
- Issue :
- 6B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 16312042