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Addition of grignard reagents to aryl acid chlorides: an efficient synthesis of aryl ketones.
- Source :
-
Organic letters [Org Lett] 2005 Dec 08; Vol. 7 (25), pp. 5593-5. - Publication Year :
- 2005
-
Abstract
- [chemical reaction: see text]. Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nucleophilic addition by Grignard reagents.
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 7
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 16320999
- Full Text :
- https://doi.org/10.1021/ol052150q