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Effects of Ge Gen Decoction on PGE2 content and COX activity in the degenarated cervical intervertebral discs of rats.
- Source :
-
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2005 Sep; Vol. 25 (3), pp. 222-5. - Publication Year :
- 2005
-
Abstract
- After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE2 content and COX activity in the model rat increased significantly, and that Ge Gen Decoction could down-regulate the PGE2 content and inhibit COX activity. This is possibly one of the mechanisms of Ge Gen Decoction for treating cervical spondylosis.
- Subjects :
- Animals
Cyclooxygenase 1 metabolism
Cyclooxygenase 2 metabolism
Drugs, Chinese Herbal pharmacology
Drugs, Chinese Herbal therapeutic use
Female
Intervertebral Disc metabolism
Male
Rats
Rats, Sprague-Dawley
Cervical Vertebrae
Dinoprostone metabolism
Phytotherapy
Prostaglandin-Endoperoxide Synthases metabolism
Spinal Osteophytosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0255-2922
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
- Publication Type :
- Academic Journal
- Accession number :
- 16334730