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[Evaluation on the safety and immunogenicity of Canada split influenza virus vaccine].
- Source :
-
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Zhonghua Liu Xing Bing Xue Za Zhi] 2005 Jul; Vol. 26 (7), pp. 503-6. - Publication Year :
- 2005
-
Abstract
- Objective: To evaluate the safety and immunogenicity of Canada split influenza virus vaccine.<br />Methods: Cluster samples were by randomly chosen and divided into split vaccination group and homoimported influenza vaccination group.<br />Results: After injection, fever-reaction and local reaction rates of 'trial' group were found as 3.69% and 1.75% respectively, but no statistical significance was found when compared with 'control' group. However the antibody positive rates of 'trail' and 'control' groupsappeared statistically significant (H1N1: 96.8% vs. 92.3%, H3N2: 95.8% vs. 90.2%, B: 52.3% vs. 62.3%). For geometric mean titer (GMT) of type H1N1, H3H2 and B antibody, 'trial' group and 'control' group increased 22.4, 16.8, 8.2 and 21.2, 12.5 and 7.4 times respectively. The antibody protective rates of type H1N1, H3N2 and B were 99%, 99% and 53.9% for 'trial' group, and 96.2%, 98.4% and 62.3% for 'control' but with no statistically significant difference.<br />Conclusion: Influenza split vaccine made in Shire company in Canada was safe and with good immunogenicity.
- Subjects :
- Adolescent
Adult
Age Factors
Antibody Formation immunology
Canada
Child
Child, Preschool
Female
Humans
Infant
Injections
Male
Middle Aged
Time Factors
Viral Vaccines administration & dosage
Young Adult
Drug-Related Side Effects and Adverse Reactions immunology
Orthomyxoviridae immunology
Viral Vaccines adverse effects
Viral Vaccines immunology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0254-6450
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- 16335001