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Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
- Source :
-
Nature immunology [Nat Immunol] 2006 Feb; Vol. 7 (2), pp. 173-8. Date of Electronic Publication: 2005 Dec 20. - Publication Year :
- 2006
-
Abstract
- Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant responses in human immunodeficiency virus infection, we analyzed cytotoxic T lymphocyte responses restricted by HLA-B*1503, a rare allele in a cohort infected with clade B, although common in one infected with clade C. HLA-B*1503 was associated with reduced viral loads in the clade B cohort but not the clade C cohort, although both shared the immunodominant response. Clade B viral control was associated with responses to several subdominant cytotoxic T lymphocyte epitopes, whereas their clade C variants were less well recognized. These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations.
- Subjects :
- AIDS Vaccines immunology
Amino Acid Sequence
Cohort Studies
Epitope Mapping
Epitopes genetics
Genetic Variation
HIV Infections genetics
HIV Infections virology
HIV-1 classification
HIV-1 genetics
HLA-B Antigens genetics
HLA-B15 Antigen
Humans
Immunodominant Epitopes genetics
In Vitro Techniques
Molecular Sequence Data
HIV Antigens genetics
HIV Infections immunology
HIV-1 immunology
HIV-1 physiology
T-Lymphocytes, Cytotoxic immunology
Virus Replication immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2908
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16369537
- Full Text :
- https://doi.org/10.1038/ni1281